Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells
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چکیده
منابع مشابه
Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells
Citicoline and homotaurine are renowned compounds that exhibit potent neuroprotective activities through distinct molecular mechanisms. The present study was undertaken to demonstrate whether cotreatment with citicoline and homotaurine affects cell survival in primary retinal cultures under experimental conditions simulating retinal neurodegeneration. Primary cultures were obtained from the ret...
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15 صفحه اولProtective action of zinc against glutamate neurotoxicity in cultured retinal neurons.
PURPOSE To examine the effects of Zn2+ on glutamate-induced neurotoxicity in cultured retinal neurons. METHODS Primary cultures obtained from fetal rat retinas (16 to 19 days gestation) were used. The neurotoxic effects of excitatory amino acids were quantitatively assessed using the trypan blue exclusion method. RESULTS A brief exposure of retinal cultures to glutamate or N-methyl-D-aspart...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2017
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2017/2825703